MACF1 antibody (AA 1936-2150)

Catalog No. ABIN7159742

Product Details anti-MACF1 Antibody

Target: MACF1 (Microtubule-Actin Crosslinking Factor 1 (MACF1))

Binding Specificity: AA 1936-2150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MACF1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 protein (1936-2150AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MACF1

Target: MACF1 (Microtubule-Actin Crosslinking Factor 1 (MACF1))

Alternative Name: MACF1 (MACF1 Products)

Synonyms: ABP620 antibody, ACF7 antibody, MACF antibody, OFC4 antibody, Acf7 antibody, Aclp7 antibody, R74989 antibody, mKIAA0465 antibody, MACF1 antibody, fc46g01 antibody, wu:fc46g01 antibody, si:rp71-45k5.7 antibody, acf7 antibody, macf antibody, ofc4 antibody, abp620 antibody, DKFZp469K2016 antibody, Kiaa0754 antibody, mKIAA0754 antibody, microtubule-actin crosslinking factor 1 antibody, microtubule-actin crosslinking factor 1a antibody, microtubule-actin cross-linking factor 1 antibody, dual specificity protein kinase CLK3 antibody, microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 antibody, KIAA0754 antibody, RIKEN cDNA D830031N03 gene antibody, MACF1 antibody, Macf1 antibody, macf1a antibody, macf1 antibody, LOC100175356 antibody, LOC100514848 antibody, LOC100550622 antibody, KIAA0754 antibody, D830031N03Rik antibody

Background:

Background: Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells (By similarity).

Aliases: MACF1 antibody, ABP620 antibody, ACF7 antibody, KIAA0465 antibody, KIAA1251 antibody, Microtubule-actin cross-linking factor 1 antibody, isoforms 1/2/3/5 antibody, 620 kDa actin-binding protein antibody, ABP620 antibody, Actin cross-linking family protein 7 antibody, Macrophin-1 antibody, Trabeculin-alpha antibody

UniProt: Q9UPN3