TET3 antibody (AA 72-335)

Catalog No. ABIN7159638

Product Details anti-TET3 Antibody

Target: TET3 (Tet Methylcytosine Dioxygenase 3 (TET3))

Binding Specificity: AA 72-335

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TET3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Methylcytosine dioxygenase TET3 protein (72-335AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TET3

Target: TET3 (Tet Methylcytosine Dioxygenase 3 (TET3))

Alternative Name: TET3 (TET3 Products)

Synonyms: B430006D22Rik antibody, BC037432 antibody, D230004J03Rik antibody, tet methylcytosine dioxygenase 3 antibody, Tet3 antibody, TET3 antibody

Background:

Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Aliases: hCG_40738 antibody, KIAA0401 antibody, Methylcytosine dioxygenase TET3 antibody, Probable methylcytosine dioxygenase TET3 antibody, Tet methylcytosine dioxygenase 3 antibody, Tet oncogene family member 3 antibody, Tet3 antibody, TET3_HUMAN antibody

UniProt: O43151

Pathways: Warburg Effect