TET1 antibody (AA 1700-1800)

Catalog No. ABIN7159633

Product Details anti-TET1 Antibody

Target: TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))

Binding Specificity: AA 1700-1800

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TET1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Methylcytosine dioxygenase TET1 protein (1700-1800AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TET1

Target: TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))

Alternative Name: TET1 (TET1 Products)

Synonyms: CXXC6 antibody, LCX antibody, bA119F7.1 antibody, 2510010B09Rik antibody, AA517754 antibody, BB001228 antibody, Cxxc6 antibody, D10Ertd17e antibody, mKIAA1676 antibody, tet methylcytosine dioxygenase 1 antibody, solute carrier family 25 member 16 antibody, TET1 antibody, Tet1 antibody, SLC25A16 antibody

Background:

Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).

Aliases: bA119F7.1 antibody, CXXC 6 antibody, CXXC finger 6 antibody, CXXC type zinc finger protein 6 antibody, CXXC zinc finger 6 antibody, CXXC-type zinc finger protein 6 antibody, CXXC6 antibody, KIAA1676 antibody, LCX antibody, Leukemia associated protein with a CXXC domain antibody, Leukemia-associated protein with a CXXC domain antibody, Methylcytosine dioxygenase TET1 antibody, Ten eleven translocation 1 antibody, Ten eleven translocation 1 gene protein antibody, Ten eleven translocation 1 gene protein homolog antibody, Ten-eleven translocation 1 gene protein antibody, Tet 1 antibody, Tet methylcytosine dioxygenase 1 antibody, Tet oncogene 1 antibody, TET1 antibody, TET1_HUMAN antibody

UniProt: Q8NFU7

Pathways: Stem Cell Maintenance, Warburg Effect