STEAP1 antibody (AA 3-69)

Catalog No. ABIN7159501

Product Details anti-STEAP1 Antibody

Target: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Binding Specificity: AA 3-69

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STEAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Metalloreductase STEAP1 protein (3-69AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for STEAP1

Target: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Alternative Name: STEAP1 (STEAP1 Products)

Synonyms: PRSS24 antibody, STEAP antibody, STEAP1 antibody, 2410007B19Rik antibody, Prss24 antibody, Steap antibody, STEAP family member 1 antibody, six transmembrane epithelial antigen of the prostate 1 antibody, STEAP1 antibody, Steap1 antibody

Background:

Background: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis By similarity. Mediates \\\'Lys-63\\\'-linked polyubiquitination of TBK1, which probably participates in kinase activation.

Aliases: 2410007B19Rik antibody, EC 1.16.1.- antibody, Metalloreductase STEAP1 antibody, MGC19484 antibody, PRSS 24 antibody, PRSS24 antibody, Six transmembrane epithelial antigen of prostate antibody, Six transmembrane epithelial antigen of the prostate 1 antibody, Six transmembrane epithelial antigen of the prostate antibody, Six-transmembrane epithelial antigen of prostate 1 antibody, STEA1_HUMAN antibody, STEAP 1 antibody, Steap antibody, STEAP1 antibody

UniProt: Q9UHE8

Pathways: Transition Metal Ion Homeostasis