Merlin antibody (AA 230-414)

Catalog No. ABIN7159413

Product Details anti-Merlin Antibody

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Binding Specificity: AA 230-414

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Merlin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Merlin protein (230-414AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Alternative Name: NF2 (NF2 Products)

Synonyms: ACN antibody, BANF antibody, SCH antibody, NF2 antibody, merlin antibody, zgc:194620 antibody, zgc:194631 antibody, NF2a antibody, nf2 antibody, neurofibromin 2 antibody, neurofibromin 2a (merlin) antibody, neurofibromin 2b (merlin) antibody, neurofibromin 2 (merlin) S homeolog antibody, NF2 antibody, Nf2 antibody, nf2a antibody, nf2b antibody, nf2.S antibody

Background:

Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Aliases: ACN antibody, BANF antibody, Bilateral acoustic neuroma antibody, MERL_HUMAN antibody, Merlin antibody, Moesin ezrin radixin like protein antibody, Moesin ezrin radizin like antibody, Moesin-ezrin-radixin-like protein antibody, Neurofibromatosis 2 antibody, Neurofibromatosis type 2 antibody, Neurofibromatosis2 antibody, Neurofibromin 2 antibody, Neurofibromin-2 antibody, Neurofibromin2 antibody, NF 2 antibody, Nf2 antibody, SCH antibody, Schwannomerlin antibody, Schwannomin antibody

UniProt: P35240

Pathways: Cell-Cell Junction Organization