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MAGEA2 antibody (AA 1-104) (FITC)

MAGEA2 Reactivity: Human Host: Rabbit Polyclonal FITC
Catalog No. ABIN7159258
  • Target See all MAGEA2 Antibodies
    MAGEA2 (Melanoma Antigen Family A, 2 (MAGEA2))
    Binding Specificity
    • 7
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 1-104
    Reactivity
    • 28
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 26
    • 2
    Rabbit
    Clonality
    • 26
    • 2
    Polyclonal
    Conjugate
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAGEA2 antibody is conjugated to FITC
    Application
    Please inquire
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Melanoma-associated antigen 2 protein (1-104AA)
    Isotype
    IgG
    Top Product
    Discover our top product MAGEA2 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    MAGEA2 (Melanoma Antigen Family A, 2 (MAGEA2))
    Alternative Name
    MAGEA2 (MAGEA2 Products)
    Synonyms
    Mage-a2 antibody, MAGEA2 antibody, CT1.2 antibody, MAGE2 antibody, MAGEA2A antibody, melanoma antigen, family A, 2 antibody, melanoma-associated antigen 2 antibody, MAGE family member A2 antibody, Magea2 antibody, LOC706218 antibody, MAGEA2 antibody
    Background

    Background: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

    Aliases: MAGEA2 antibody, MAGE2 antibody, MAGEA2A, antibody, MAGEA2B antibody, MAGE2 antibody, MAGEA2 antibody, Melanoma-associated antigen 2 antibody, Cancer/testis antigen 1.2 antibody, CT1.2 antibody, MAGE-2 antigen antibody

    UniProt
    P43356
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