SPO11 antibody (AA 28-109)

Catalog No. ABIN7159201

Product Details anti-SPO11 Antibody

Target: SPO11 (SPO11 Meiotic Protein Covalently Bound To DSB Homolog (SPO11))

Binding Specificity: AA 28-109

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPO11 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Meiotic recombination protein SPO11 protein (28-109AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SPO11

Target: SPO11 (SPO11 Meiotic Protein Covalently Bound To DSB Homolog (SPO11))

Alternative Name: SPO11 (SPO11 Products)

Synonyms: CT35 antibody, SPATA43 antibody, TOPVIA antibody, zgc:77876 antibody, AI449549 antibody, Meiotic recombination protein spo-11 antibody, SPO11, initiator of meiotic double stranded breaks antibody, SPO11 meiotic protein covalently bound to DSB antibody, spo-11 antibody, SPO11 antibody, Spo11 antibody, spo11 antibody

Background:

Background: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.

Aliases: Cancer/testis antigen 35 antibody, CT35 antibody, Meiotic recombination protein SPO 11 antibody, Meiotic recombination protein SPO11 antibody, MGC39953 antibody, SPATA43 antibody, Spermatogenesis associated 43 antibody, SPO 11 antibody, SPO11 antibody, SPO11 meiotic protein covalently bound to DSB antibody, SPO11 meiotic protein covalently bound to DSB homolog antibody, SPO11 meiotic protein covalently bound to DSB like antibody, SPO11_HUMAN antibody, TOPVIA antibody

UniProt: Q9Y5K1