RIKEN cDNA 4930404A10 Gene (4930404A10RIK) (AA 18-91) antibody (HRP)

Catalog No. ABIN7159186

Product Details

Target: RIKEN cDNA 4930404A10 Gene (4930404A10RIK)

Binding Specificity: AA 18-91

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Meiosis-specific kinetochore protein (18-91AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: RIKEN cDNA 4930404A10 Gene (4930404A10RIK)

Alternative Name: MEIKIN (4930404A10RIK Products)

Synonyms: 4930404A10Rik antibody, meiotic kinetochore factor antibody, Meikin antibody

Background:

Background: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.

Aliases: MEIKINMeiosis-specific kinetochore protein antibody

UniProt: A0A087WXM9