MCTS1 antibody (AA 1-181)

Catalog No. ABIN7158949

Product Details anti-MCTS1 Antibody

Target: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Binding Specificity: AA 1-181

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCTS1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Malignant T-cell-amplified sequence 1 protein (1-181AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MCTS1

Target: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Alternative Name: MCTS1 (MCTS1 Products)

Synonyms: MCT-1 antibody, MCT1 antibody, MCT1a antibody, cb517 antibody, zgc:55682 antibody, 1500019M23Rik antibody, zgc:56242 antibody, mcts1 antibody, MGC89874 antibody, MCTS1 antibody, MCT-1A antibody, mct-1 antibody, mct1 antibody, MCT-1B antibody, mcts1-a antibody, mcts1-b antibody, MCTS1, re-initiation and release factor antibody, solute carrier family 16 (monocarboxylate transporter), member 1b antibody, malignant T cell amplified sequence 1 antibody, malignant T-cell amplified sequence 1 antibody, solute carrier family 16 member 1 antibody, malignant T-cell amplified sequence 1 S homeolog antibody, monocarboxylate transporter 1 antibody, malignant T-cell amplified sequence 1 L homeolog antibody, MCTS1 antibody, slc16a1b antibody, Mcts1 antibody, mcts1 antibody, SLC16A1 antibody, mcts1.S antibody, MCT1 antibody, mcts1.L antibody

Background:

Background: Anti-oncogene that play a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation, promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer, recruits the density-regulated protein/DENR and binds to the cap complex of the 5\'-terminus of mRNAs, subsequently altering the mRNA translation profile, up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation, promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

Aliases: FLJ39637 antibody, Malignant T cell amplified sequence 1 antibody, Malignant T cell-amplified sequence 1 antibody, MCT 1 antibody, MCT-1 antibody, MCT1 antibody, MCTS 1 antibody, MCTS1 antibody, MCTS1_HUMAN antibody, Multiple copies T cell malignancies 1 antibody, Multiple copies T cell malignancies antibody, Multiple copies T-cell malignancies antibody, Oncogene MCT 1 antibody, Oncogene MCT1 antibody

UniProt: Q9ULC4