MST1R antibody (AA 1175-1400)

Catalog No. ABIN7158896

Product Details anti-MST1R Antibody

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Binding Specificity: AA 1175-1400

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MST1R antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Macrophage-stimulating protein receptor protein (1175-1400AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MST1R

Target: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Alternative Name: MST1R (MST1R Products)

Synonyms: CD136 antibody, CDw136 antibody, PTK8 antibody, RON antibody, Fv-2 antibody, Fv2 antibody, Ron antibody, STK antibody, Cdw136 antibody, Ptk8 antibody, Stk antibody, macrophage stimulating 1 receptor antibody, macrophage stimulating 1 receptor (c-met-related tyrosine kinase) antibody, MST1R antibody, Mst1r antibody

Background:

Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Aliases: c met related tyrosine kinase antibody, CD136 antibody, CD136 antigen antibody, CDw136 antibody, Macrophage stimulating 1 receptor (c met related tyrosine kinase) antibody, Macrophage stimulating 1 receptor antibody, Macrophage stimulating protein receptor alpha chain antibody, MACROPHAGE STIMULATING PROTEIN RECEPTOR antibody, Macrophage stimulating protein receptor beta chain antibody, Macrophage-Stimulating 1 Receptor (MST1R) antibody, Macrophage-stimulating protein receptor beta chain antibody, MSP receptor antibody, Mst1r antibody, MST1R variant RON30 antibody, MST1R variant RON62 antibody, NPCA3 antibody, p185 RON antibody, p185-Ron antibody, Protein-tyrosine kinase 8 antibody, PTK 8 antibody, ptk8 antibody, PTK8 protein tyrosine kinase 8 antibody, Recepteur drigine nantais (RON) antibody, RON antibody, RON protein tyrosine kinase antibody, RON variant E2E3 antibody, RON_HUMAN antibody, Soluble RON variant 1 antibody, Soluble RON variant 2 antibody, Soluble RON variant 3 antibody, Soluble RON variant 4 antibody, Stem cell derived tyrosine kinase antibody

UniProt: Q04912

Pathways: RTK Signaling