KDM6A antibody (AA 620-749)

Catalog No. ABIN7158716

Product Details anti-KDM6A Antibody

Target: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Binding Specificity: AA 620-749

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM6A antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Lysine-specific demethylase 6A protein (620-749AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KDM6A

Target: KDM6A (Lysine (K)-Specific Demethylase 6A (KDM6A))

Alternative Name: KDM6A (KDM6A Products)

Synonyms: KABUK2 antibody, UTX antibody, bA386N14.2 antibody, Utx antibody, si:ch211-222m21.1 antibody, utx antibody, kdm6a antibody, tutx antibody, uty antibody, xtutx antibody, lysine demethylase 6A antibody, lysine-specific demethylase 6A antibody, lysine (K)-specific demethylase 6A antibody, lysine demethylase 6A S homeolog antibody, KDM6A antibody, LOC100539898 antibody, Kdm6a antibody, kdm6a antibody, kdm6a.S antibody

Background:

Background: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849).

Aliases: bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX) antibody, bA386N14.2 antibody, bA386N14.2 ubiquitously transcribed X chromosome tetratricopeptide repeat protein UTX antibody, DKFZp686A03225 antibody, Histone demethylase UTX antibody, KABUK2 antibody, Kdm6a antibody, KDM6A_HUMAN antibody, Lysine (K) specific demethylase 6A antibody, Lysine K specific demethylase 6A antibody, Lysine specific demethylase 6A ubiquitously transcribed tetratricopeptide repeat gene X chromosome antibody, Lysine-specific demethylase 6A antibody, MGC141941 antibody, Ubiquitously transcribed tetratricopeptide repeat X chromosome antibody, Ubiquitously transcribed tetratricopeptide repeat protein X linked antibody, Ubiquitously transcribed TPR gene on the X chromosome antibody, Ubiquitously transcribed TPR protein on the X chromosome antibody, Ubiquitously transcribed X chromosome tetratricopeptide repeat protein antibody, Ubiquitously-transcribed TPR protein on the X chromosome antibody, Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein antibody, UTX antibody

UniProt: O15550

Pathways: Tube Formation, Warburg Effect