LRP8 antibody (AA 131-332) (FITC)
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- Target See all LRP8 Antibodies
- LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))
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Binding Specificity
- AA 131-332
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LRP8 antibody is conjugated to FITC
- Application
- Please inquire
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Low-density lipoprotein receptor-related protein 8 protein (131-332AA)
- Isotype
- IgG
- Top Product
- Discover our top product LRP8 Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))
- Alternative Name
- LRP8 (LRP8 Products)
- Synonyms
- LRP8 antibody, APOER2 antibody, HSZ75190 antibody, LRP-8 antibody, MCI1 antibody, 4932703M08Rik antibody, AA921429 antibody, AI848122 antibody, ApoER2 antibody, Lr8b antibody, LR8B antibody, LDL receptor related protein 8 antibody, low density lipoprotein receptor-related protein 8, apolipoprotein e receptor antibody, LRP8 antibody, Lrp8 antibody
- Background
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Background: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
Aliases: APOER2 antibody, Apolipoprotein E receptor 2 antibody, low density lipoprotein receptor-related protein 8 antibody, Low-density lipoprotein receptor-related protein 8 antibody, LRP-8 antibody, LRP8 antibody, LRP8_HUMAN antibody
- UniProt
- Q14114
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