LILRB1 antibody (AA 483-650)

Catalog No. ABIN7158264

Product Details anti-LILRB1 Antibody

Target: LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))

Binding Specificity: AA 483-650

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LILRB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 1 protein (483-650AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LILRB1

Target: LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))

Alternative Name: LILRB1 (LILRB1 Products)

Synonyms: CD85J antibody, ILT-2 antibody, ILT2 antibody, LIR-1 antibody, LIR1 antibody, MIR-7 antibody, MIR7 antibody, leukocyte immunoglobulin like receptor B1 antibody, LILRB1 antibody

Background:

Background: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Aliases: CD85 antibody, CD85 antigen antibody, CD85 antigen like family member J antibody, CD85 antigen-like family member J antibody, CD85j antibody, CD85j antigen antibody, Ig like transcript 2 antibody, ILT 2 antibody, ILT-2 antibody, ILT2 antibody, immunoglobulin like transcript 2 antibody, Immunoglobulin-like transcript 2 antibody, leukocyte Ig like receptor 1 antibody, Leukocyte immunoglobulin like receptor 1 antibody, leukocyte immunoglobulin like receptor subfamily B member 1 antibody, Leukocyte immunoglobulin like receptor subfamily B member 1 precursor antibody, leukocyte immunoglobulin like receptor subfamily B member 1 soluble isoform antibody, leukocyte immunoglobulin like receptor, subfamily B, member 1 antibody, Leukocyte immunoglobulin-like receptor 1 antibody, Leukocyte immunoglobulin-like receptor subfamily B member 1 antibody, leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform antibody, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 antibody, LILRB1 antibody, LIR 1 antibody, LIR-1 antibody, LIR1 antibody, LIRB1_HUMAN antibody, MIR 7 antibody, MIR-7 antibody, MIR7 antibody, Monocyte/macrophage immunoglobulin like receptor 7 antibody, Monocyte/macrophage immunoglobulin-like receptor 7 antibody, PIR B antibody, PIRB antibody

UniProt: Q8NHL6

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response