LGR5 antibody (AA 241-352)

Catalog No. ABIN7158130

Product Details anti-LGR5 Antibody

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Binding Specificity: AA 241-352

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGR5 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 5 protein (241-352AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LGR5

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Alternative Name: LGR5 (LGR5 Products)

Synonyms: lgr5-a antibody, lgr5a antibody, FEX antibody, Gpr49 antibody, GPR49 antibody, GPR67 antibody, GRP49 antibody, HG38 antibody, leucine-rich repeat containing G protein-coupled receptor 5 L homeolog antibody, leucine rich repeat containing G protein coupled receptor 5 antibody, leucine rich repeat containing G protein-coupled receptor 5 antibody, lgr5.L antibody, Lgr5 antibody, LGR5 antibody

Background:

Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Aliases: FEX antibody, G protein coupled receptor 49 antibody, G protein coupled receptor 67 antibody, g protein-coupled receptor fex antibody, G-protein coupled receptor 49 antibody, G-protein coupled receptor 67 antibody, G-protein coupled receptor HG38 antibody, GPCR GPR49 antibody, GPR 49 antibody, GPR 67 antibody, GPR49 antibody, GPR67 antibody, GRP 49 antibody, GRP49 antibody, HG 38 antibody, HG38 antibody, Leucine rich repeat containing G protein coupled receptor 5 antibody, Leucine-rich repeat-containing G-protein coupled receptor 5 antibody, LGR 5 antibody, LGR5 antibody, LGR5_HUMAN antibody, MGC117008 antibody, Orphan G protein coupled receptor HG38 antibody

UniProt: O75473

Pathways: WNT Signaling