LRRK2 antibody (AA 2029-2275)
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- Target See all LRRK2 Antibodies
- LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
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Binding Specificity
- AA 2029-2275
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LRRK2 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 protein (2029-2275AA)
- Isotype
- IgG
- Top Product
- Discover our top product LRRK2 Primary Antibody
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- Application Notes
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
- Alternative Name
- LRRK2 (LRRK2 Products)
- Synonyms
- LRRK2 antibody, AURA17 antibody, DARDARIN antibody, PARK8 antibody, RIPK7 antibody, ROCO2 antibody, 4921513O20Rik antibody, 9330188B09Rik antibody, AW561911 antibody, D630001M17Rik antibody, Gm927 antibody, cI-46 antibody, leucine-rich repeat kinase 2 antibody, leucine rich repeat kinase 2 antibody, lrrk2 antibody, LRRK2 antibody, Lrrk2 antibody
- Background
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Background: Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH , and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
Aliases: augmented in rheumatoid arthritis 17 antibody, AURA17 antibody, Dardarin antibody, Leucine rich repeat kinase 2 antibody, leucine rich repeat serine threonine protein kinase 2 antibody, Leucine-rich repeat serine/threonine-protein kinase 2 antibody, LRRK 2 antibody, LRRK2 antibody, LRRK2_HUMAN antibody, PARK 8 antibody, PARK8 antibody, RIPK7 antibody, ROCO 2 antibody, ROCO2 antibody
- UniProt
- Q5S007
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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