LRPPRC antibody (AA 901-1036)

Catalog No. ABIN7158045

Product Details anti-LRPPRC Antibody

Target: LRPPRC (Leucine-Rich PPR-Motif Containing (LRPPRC))

Binding Specificity: AA 901-1036

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRPPRC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Leucine-rich PPR motif-containing protein, mitochondrial protein (901-1036AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LRPPRC

Target: LRPPRC (Leucine-Rich PPR-Motif Containing (LRPPRC))

Alternative Name: LRPPRC (LRPPRC Products)

Synonyms: CLONE-23970 antibody, GP130 antibody, LRP130 antibody, LSFC antibody, Lrp157 antibody, 3110001K13Rik antibody, C76645 antibody, Gp130 antibody, Lrp130 antibody, Lsfc antibody, leucine rich pentatricopeptide repeat containing antibody, leucine-rich pentatricopeptide repeat containing antibody, leucine-rich PPR-motif containing antibody, LRPPRC antibody, Lrpprc antibody

Background:

Background: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).

Aliases: 130 kDa leucine-rich protein antibody, gp130 antibody, Leucine-rich PPR motif-containing protein antibody, Leucine-rich PPR-motif containing protein antibody, LPPRC_HUMAN antibody, LRP 130 antibody, lrpprc antibody, mitochondrial antibody

UniProt: P42704