KANK2 antibody (AA 410-585) (Biotin)

Catalog No. ABIN7157691

Product Details anti-KANK2 Antibody (Biotin)

Target: KANK2 (KN Motif and Ankyrin Repeat Domains 2 (KANK2))

Binding Specificity: AA 410-585

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KANK2 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human KN motif and ankyrin repeat domain-containing protein 2 protein (410-585AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KANK2

Target: KANK2 (KN Motif and Ankyrin Repeat Domains 2 (KANK2))

Alternative Name: KANK2 (KANK2 Products)

Synonyms: ANKRD25 antibody, MXRA3 antibody, SIP antibody, AI504612 antibody, Ankrd25 antibody, BC010245 antibody, KN motif and ankyrin repeat domains 2 antibody, KANK2 antibody, Kank2 antibody

Background:

Background: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm, the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis, proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation (By similarity).

Aliases: KANK2 antibody, ANKRD25 antibody, KIAA1518 antibody, MXRA3 antibody, SIP antibody, KN motif and ankyrin repeat domain-containing protein 2 antibody, Ankyrin repeat domain-containing protein 25 antibody, Matrix-remodeling-associated protein 3 antibody, SRC-1-interacting protein antibody, SIP antibody, SRC-interacting protein antibody, SRC1-interacting protein antibody

UniProt: Q63ZY3