KLHL22 antibody (AA 2-300) (Biotin)

Catalog No. ABIN7157282

Product Details anti-KLHL22 Antibody (Biotin)

Target: KLHL22 (Kelch-Like 22 (KLHL22))

Binding Specificity: AA 2-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLHL22 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Kelch-like protein 22 protein (2-300AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KLHL22

Target: KLHL22 (Kelch-Like 22 (KLHL22))

Alternative Name: KLHL22 (KLHL22 Products)

Synonyms: 2610318I18Rik antibody, Kelchl antibody, KELCHL antibody, RGD1306288 antibody, kelch-like 22 antibody, kelch like family member 22 antibody, kelch-like family member 22 antibody, Klhl22 antibody, KLHL22 antibody

Background:

Background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

Aliases: KLHL22Kelch-like protein 22 antibody

UniProt: Q53GT1