JMY antibody (AA 708-848)
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- Target See all JMY Antibodies
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
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Binding Specificity
- AA 708-848
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This JMY antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Junction-mediating and -regulatory protein (708-848AA)
- Isotype
- IgG
- Top Product
- Discover our top product JMY Primary Antibody
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- Application Notes
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- Alternative Name
- JMY (JMY Products)
- Synonyms
- WHDC1L3 antibody, junction mediating and regulatory protein, p53 cofactor antibody, junction-mediating and regulatory protein antibody, JMY antibody, jmy antibody, Jmy antibody
- Background
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Background: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).
Aliases: FLJ37870 antibody, Jmy antibody, JMY protein antibody, JMY_HUMAN antibody, junction mediating and regulatory protein antibody, Junction mediating and regulatory protein p53 cofactor antibody, Junction-mediating and -regulatory protein antibody, MGC163496 antibody, OTTHUMP00000161976 antibody, WAS protein homology region 2 domain containing 1-like 3 antibody, WHDC1L3 antibody
- UniProt
- Q8N9B5
- Pathways
- Regulation of Actin Filament Polymerization
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