IREB2 antibody (AA 107-216)

Catalog No. ABIN7157046

Product Details anti-IREB2 Antibody

Target: IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))

Binding Specificity: AA 107-216

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IREB2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Iron-responsive element-binding protein 2 protein (107-216AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IREB2

Target: IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))

Alternative Name: IREB2 (IREB2 Products)

Synonyms: IREB2 antibody, im:7153062 antibody, DKFZp468N047 antibody, D9Ertd85e antibody, Irp2 antibody, ACO3 antibody, IRP2 antibody, IRP2AD antibody, IREBP2 antibody, iron responsive element binding protein 2 antibody, iron-responsive element binding protein 2 antibody, iron responsive element binding protein 2 L homeolog antibody, IREB2 antibody, ireb2 antibody, Ireb2 antibody, ireb2.L antibody

Background:

Background: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5\\\'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3\\\'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

Aliases: ACO3 antibody, FLJ23381 antibody, IRE BP2 antibody, IRE-BP 2 antibody, IREB 2 antibody, IREB2 antibody, IREB2_HUMAN antibody, Iron regulatory protein 2 antibody, iron responsive element binding protein 2 antibody, Iron-responsive element-binding protein 2 antibody, IRP 2 antibody, IRP2 antibody, IRP2AD antibody, OTTHUMP00000185022 antibody

UniProt: P48200

Pathways: Transition Metal Ion Homeostasis