Inversin antibody (AA 1-101) (Biotin)

Catalog No. ABIN7157009

Product Details anti-Inversin Antibody (Biotin)

Target: Inversin (INVS)

Binding Specificity: AA 1-101

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Inversin antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Inversin protein (1-101AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Inversin

Target: Inversin (INVS)

Alternative Name: INVS (INVS Products)

Background:

Background: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).

Aliases: INVS antibody, INV antibody, NPHP2 antibody, Inversin antibody, Inversion of embryo turning homolog antibody, Nephrocystin-2 antibody

UniProt: Q9Y283