PRKRA antibody (AA 1-313)
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- Target See all PRKRA Antibodies
- PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))
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Binding Specificity
- AA 1-313
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PRKRA antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Interferon-inducible double-stranded RNA-dependent protein kinase activator A protein (1-313AA)
- Isotype
- IgG
- Top Product
- Discover our top product PRKRA Primary Antibody
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- Application Notes
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))
- Alternative Name
- PRKRA (PRKRA Products)
- Synonyms
- PRKRA antibody, AV120107 antibody, PRK antibody, Pact antibody, RAX antibody, lear antibody, DYT16 antibody, PACT antibody, im:7151758 antibody, zgc:162619 antibody, dyt16 antibody, pact antibody, prkra-a antibody, prkra-b antibody, rax antibody, rbpa antibody, protein activator of interferon induced protein kinase EIF2AK2 antibody, protein kinase, interferon inducible double stranded RNA dependent activator antibody, protein kinase, interferon-inducible double stranded RNA dependent activator antibody, protein activator of interferon induced protein kinase EIF2AK2 L homeolog antibody, PRKRA antibody, Prkra antibody, prkra antibody, prkra.L antibody
- Background
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Background: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at \\\'Lys-386\\\' at \\\'Ser-392\\\' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).
Aliases: DYT16 antibody, HSD14 antibody, Interferon inducible double stranded RNA dependent protein kinase activator A antibody, interferon-inducible double stranded RNA-dependent activator antibody, Interferon-inducible double stranded RNA-dependent protein kinase activator A antibody, PACT antibody, PKR associated protein X antibody, PKR associating protein X antibody, PKR-associated protein X antibody, PKR-associating protein X antibody, PRKRA antibody, PRKRA_HUMAN antibody, Protein activator of the interferon induced protein kinase antibody, Protein activator of the interferon-induced protein kinase antibody, Protein kinase antibody, Protein kinase interferon inducible double stranded RNA dependent activator antibody, RAX antibody
- UniProt
- O75569
- Pathways
- Regulatory RNA Pathways
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