IFIT1 antibody (AA 1-181)

Catalog No. ABIN7156663

Product Details anti-IFIT1 Antibody

Target: IFIT1 (Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1))

Binding Specificity: AA 1-181

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Interferon-induced protein with tetratricopeptide repeats 1 protein (1-181AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IFIT1

Target: IFIT1 (Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1))

Alternative Name: IFIT1 (IFIT1 Products)

Background:

Background: Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5\\\'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2\\\'-O-methylation of the 5\\\' cap and bear a 5\\\'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2\\\'-O-methylase for their mRNAs or by stealing host cap containing the 2\\\'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

Aliases: C56 antibody, G10P1 antibody, GARG 16 antibody, GARG16 antibody, IFI 56 antibody, IFI 56K antibody, IFI-56K antibody, IFI56 antibody, IFIT-1 antibody, Ifit1 antibody, IFIT1_HUMAN antibody, IFNAI1 antibody, Interferon alpha inducible protein (MW 56kD) antibody, Interferon induced 56 kDa protein antibody, Interferon induced protein 56 antibody, Interferon inducible mRNA 561 antibody, Interferon-induced 56 kDa protein antibody, Interferon-induced protein with tetratricopeptide repeats 1 antibody, ISG56 antibody, OTTHUMP00000020062 antibody, P56 antibody, RNM561 antibody

UniProt: P09914

Pathways: Hepatitis C