IRF9 antibody (AA 44-180)

Catalog No. ABIN7156637

Product Details anti-IRF9 Antibody

Target: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Binding Specificity: AA 44-180

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF9 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Interferon regulatory factor 9 protein (44-180AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IRF9

Target: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Alternative Name: IRF9 (IRF9 Products)

Synonyms: IRF-9 antibody, ISGF3 antibody, ISGF3G antibody, p48 antibody, zgc:92097 antibody, Irf-9 antibody, Isgf3g antibody, interferon regulatory factor 9 antibody, IRF9 antibody, irf9 antibody, Irf9 antibody

Background:

Background: Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Aliases: IFN alpha responsive transcription factor subunit antibody, IFN-alpha-responsive transcription factor subunit antibody, Interferon regulatory factor 9 antibody, interferon stimulated transcription factor 3 antibody, Interferon-stimulated gene factor 3 gamma antibody, interferon-stimulated transcription factor 3, gamma 48 kDa antibody, IRF 9 antibody, IRF-9 antibody, Irf9 antibody, IRF9_HUMAN antibody, ISGF 3 gamma antibody, ISGF-3 gamma antibody, ISGF3 antibody, ISGF3 p48 subunit antibody, ISGF3G antibody, OTTHUMP00000164692 antibody, OTTHUMP00000164693 antibody, p48 antibody, Transcriptional regulator ISGF3 subunit gamma antibody

UniProt: Q00978

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, Hepatitis C