ITGA5 antibody (AA 220-472)

Catalog No. ABIN7156442

Product Details anti-ITGA5 Antibody

Target: ITGA5 (Integrin, alpha 5 (ITGA5))

Binding Specificity: AA 220-472

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Integrin alpha-5 protein (220-472AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ITGA5

Target: ITGA5 (Integrin, alpha 5 (ITGA5))

Alternative Name: ITGA5 (ITGA5 Products)

Synonyms: ITGA5 antibody, Cd49e antibody, Fnra antibody, VLA5 antibody, CD49e antibody, FNRA antibody, VLA5A antibody, Itga5_retired antibody, integrin subunit alpha 5 antibody, integrin alpha 5 (fibronectin receptor alpha) antibody, ITGA5 antibody, Itga5 antibody

Background:

Background: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).

Aliases: CD49 antigen-like family member E antibody, CD49e antibody, Fibronectin receptor subunit alpha antibody, Fibronectin receptor, alpha subunit antibody, FNRA antibody, Integrin alpha 5 (fibronectin receptor alpha) antibody, Integrin alpha-5 antibody, Integrin alpha-5 light chain antibody, Integrin alpha-F antibody, Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) antibody, ITA5_HUMAN antibody, Itga5 antibody, Very late activation protein 5, alpha subunit antibody, VLA-5 antibody, VLA5 antibody, VLA5A antibody

UniProt: P08648

Pathways: Integrin Complex