IPO13 antibody (AA 501-700)

Catalog No. ABIN7156142

Product Details anti-IPO13 Antibody

Target: IPO13 (Importin 13 (IPO13))

Binding Specificity: AA 501-700

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IPO13 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Importin-13 protein (501-700AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IPO13

Target: IPO13 (Importin 13 (IPO13))

Alternative Name: IPO13 (IPO13 Products)

Synonyms: 3R23 antibody, CG 7212 antibody, CG7212 antibody, Dmel\\CG7212 antibody, Imp13 antibody, imp13 antibody, sd-5 antibody, DDBDRAFT_0205767 antibody, DDBDRAFT_0304414 antibody, DDB_0205767 antibody, DDB_0304414 antibody, DDBDRAFT_0191787 antibody, DDBDRAFT_0304413 antibody, DDB_0191787 antibody, DDB_0304413 antibody, IMP13 antibody, KAP13 antibody, LGL2 antibody, RANBP13 antibody, Kap13 antibody, Ranbp13 antibody, Lgl2 antibody, DKFZp459H088 antibody, cadmus antibody, importin 13 antibody, cdm antibody, IPO13 antibody, AFUA_5G08060 antibody, ANI_1_1340034 antibody, AOR_1_1272114 antibody, ipo13B antibody, ipo13A antibody, ipo13 antibody, Ipo13 antibody

Background:

Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

Aliases: Imp 13 antibody, Imp13 antibody, Importin-13 antibody, Importin13 antibody, IPO 13 antibody, Ipo13 antibody, IPO13_HUMAN antibody, Kap 13 antibody, Kap13 antibody, Karyopherin 13 antibody, Karyopherin-13 antibody, Karyopherin13 antibody, KIAA0274 antibody, Late gestation lung 2 antibody, Late gestation lung 2 protein antibody, Lgl2 antibody, Ran binding protein 13 antibody, Ran-binding protein 13 antibody, RanBP 13 antibody, RanBP13 antibody

UniProt: O94829

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Protein targeting to Nucleus