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KPNB1 antibody (AA 9-214) (Biotin)

KPNB1 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7156135
  • Target See all KPNB1 Antibodies
    KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))
    Binding Specificity
    • 15
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 9-214
    Reactivity
    • 45
    • 18
    • 17
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 42
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 43
    • 3
    Polyclonal
    Conjugate
    • 23
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KPNB1 antibody is conjugated to Biotin
    Application
    • 35
    • 13
    • 13
    • 11
    • 9
    • 5
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Importin subunit beta-1 protein (9-214AA)
    Isotype
    IgG
    Top Product
    Discover our top product KPNB1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))
    Alternative Name
    KPNB1 (KPNB1 Products)
    Synonyms
    Afu1g15720 antibody, AO090005001133 antibody, imb1 antibody, impnb antibody, ipo1 antibody, ipob antibody, ntf97 antibody, IMB1 antibody, IPO1 antibody, IPOB antibody, Impnb antibody, NTF97 antibody, AA409963 antibody, importin beta-1 subunit antibody, Importin beta-1 subunit antibody, karyopherin (importin) beta 1 L homeolog antibody, importin beta 1 antibody, karyopherin subunit beta 1 antibody, karyopherin (importin) beta 1 antibody, AFUA_1G15720 antibody, AOR_1_1974174 antibody, Bm1_57540 antibody, PMAA_065830 antibody, AFLA_083750 antibody, TSTA_085870 antibody, BDBG_07509 antibody, MCYG_00039 antibody, kpnb1.L antibody, LOC100533387 antibody, KPNB1 antibody, Kpnb1 antibody
    Background

    Background: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

    Aliases: IMB 1 antibody, IMB1 antibody, IMB1_HUMAN antibody, Impnb antibody, Importin 90 antibody, Importin beta 1 antibody, Importin beta 1 subunit antibody, Importin subunit beta-1 antibody, Importin-90 antibody, IPOB antibody, Karyopherin beta 1 antibody, Karyopherin beta 1 subunit antibody, Karyopherin subunit beta-1 antibody, KPNB 1 antibody, Kpnb1 antibody, MGC2155 antibody, MGC2156 antibody, MGC2157 antibody, NTF 97 antibody, NTF97 antibody, NTF97/Importin beta antibody, Nuclear factor P97 antibody, Pore targeting complex 97 kDa subunit antibody, PTAC97 antibody

    UniProt
    Q14974
    Pathways
    Protein targeting to Nucleus
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