KPNA6 antibody (AA 277-536)

Catalog No. ABIN7156132

Product Details anti-KPNA6 Antibody

Target: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Binding Specificity: AA 277-536

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNA6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Importin subunit alpha-7 protein (277-536AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KPNA6

Target: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Alternative Name: KPNA6 (KPNA6 Products)

Synonyms: IPOA7 antibody, Kpna5 antibody, NPI-2 antibody, KPNA7 antibody, karyopherin subunit alpha 6 antibody, karyopherin (importin) alpha 6 antibody, karyopherin alpha 6 (importin alpha 7) antibody, karyopherin alpha 6 (importin alpha 7) S homeolog antibody, KPNA6 antibody, Kpna6 antibody, kpna6.S antibody

Background:

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Aliases: FLJ11249 antibody, IMA7_HUMAN antibody, Importin alpha 7 subunit antibody, Importin alpha S2 antibody, Importin subunit alpha 7 antibody, Importin subunit alpha-7 antibody, IPOA 7 antibody, IPOA7 antibody, Karyopherin alpha 6 antibody, Karyopherin alpha 6 (importin alpha 7) antibody, Karyopherin subunit alpha 6 antibody, Karyopherin subunit alpha-6 antibody, KPNA 6 antibody, KPNA 7 antibody, Kpna6 antibody, KPNA7 antibody, MGC17918 antibody, OTTHUMP00000004532 antibody

UniProt: O60684

Pathways: Protein targeting to Nucleus