KPNA1 antibody (AA 8-538)

Catalog No. ABIN7156126

Product Details anti-KPNA1 Antibody

Target: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Binding Specificity: AA 8-538

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNA1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Importin subunit alpha-5 protein (8-538AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KPNA1

Target: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Alternative Name: KPNA1 (KPNA1 Products)

Synonyms: IPOA5 antibody, NPI-1 antibody, RCH2 antibody, SRP1 antibody, AW494490 antibody, NPI1 antibody, Rch2 antibody, mSRP1 antibody, si:ch211-161h7.7 antibody, karyopherin subunit alpha 1 antibody, importin alpha-1 subunit antibody, karyopherin (importin) alpha 1 antibody, karyopherin alpha 1 (importin alpha 5) antibody, KPNA1 antibody, Kpna1 antibody, EHI_124900 antibody, kpna1 antibody

Background:

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Aliases: IMA5_HUMAN antibody, Importin alpha 1 subunit antibody, Importin alpha 5 antibody, Importin alpha S1 antibody, Importin subunit alpha-5, N-terminally processed antibody, IPO A5 antibody, IPOA 5 antibody, IPOA5 antibody, Karyopherin alpha 1 antibody, Karyopherin alpha 1 subunit antibody, Karyopherin subunit alpha-1 antibody, KPNA 1 antibody, KPNA1 antibody, mSRP 1 antibody, mSRP1 antibody, NPI 1 antibody, NPI-1 antibody, NPI1 antibody, Nucleoprotein interactor 1 antibody, RAG cohort protein 2 antibody, RCH 2 antibody, RCH2 antibody, Recombination activating gene cohort 2 antibody, SRP 1 antibody, SRP1 beta antibody, SRP1-beta antibody

UniProt: P52294

Pathways: M Phase, Protein targeting to Nucleus