ALOXE3 antibody (AA 1-280)

Catalog No. ABIN7155980

Product Details anti-ALOXE3 Antibody

Target: ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))

Binding Specificity: AA 1-280

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALOXE3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Hydroperoxide isomerase ALOXE3 protein (1-280AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ALOXE3

Target: ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))

Alternative Name: ALOXE3 (ALOXE3 Products)

Synonyms: e-lox antibody, elox3 antibody, ARCI3 antibody, E-LOX antibody, eLOX3 antibody, e-LOX-3 antibody, ALOX15B antibody, arachidonate lipoxygenase 3 antibody, arachidonate lipoxygenase 3 L homeolog antibody, arachidonate 15-lipoxygenase, type B antibody, ALOXE3 antibody, aloxe3.L antibody, aloxe3 antibody, Aloxe3 antibody, ALOX15B antibody

Background:

Background: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.

Aliases: ALOXE3 antibody, Arachidonate lipoxygenase 3 antibody, e LOX 3 antibody, E LOX antibody, e-LOX-3 antibody, eLOX3 antibody, Epidermal lipoxygenase antibody, Epidermis-type lipoxygenase 3 antibody, Lipoxygenase 3 antibody, LOXE3_HUMAN antibody

UniProt: Q9BYJ1

Pathways: Cell-Cell Junction Organization