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ALOXE3 antibody (AA 1-280)

ALOXE3 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7155980
  • Target See all ALOXE3 Antibodies
    ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))
    Binding Specificity
    • 15
    • 8
    • 7
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-280
    Reactivity
    • 39
    • 8
    Human
    Host
    • 37
    • 2
    Rabbit
    Clonality
    • 38
    Polyclonal
    Conjugate
    • 15
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALOXE3 antibody is un-conjugated
    Application
    • 24
    • 17
    • 13
    • 13
    • 5
    • 3
    • 3
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Hydroperoxide isomerase ALOXE3 protein (1-280AA)
    Isotype
    IgG
    Top Product
    Discover our top product ALOXE3 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))
    Alternative Name
    ALOXE3 (ALOXE3 Products)
    Synonyms
    e-lox antibody, elox3 antibody, ARCI3 antibody, E-LOX antibody, eLOX3 antibody, e-LOX-3 antibody, ALOX15B antibody, arachidonate lipoxygenase 3 antibody, arachidonate lipoxygenase 3 L homeolog antibody, arachidonate 15-lipoxygenase, type B antibody, ALOXE3 antibody, aloxe3.L antibody, aloxe3 antibody, Aloxe3 antibody, ALOX15B antibody
    Background

    Background: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.

    Aliases: ALOXE3 antibody, Arachidonate lipoxygenase 3 antibody, e LOX 3 antibody, E LOX antibody, e-LOX-3 antibody, eLOX3 antibody, Epidermal lipoxygenase antibody, Epidermis-type lipoxygenase 3 antibody, Lipoxygenase 3 antibody, LOXE3_HUMAN antibody

    UniProt
    Q9BYJ1
    Pathways
    Cell-Cell Junction Organization
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