HORMAD1 antibody (AA 201-394)

Catalog No. ABIN7155897

Product Details anti-HORMAD1 Antibody

Target: HORMAD1 (HORMA Domain Containing 1 (HORMAD1))

Binding Specificity: AA 201-394

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HORMAD1 antibody is un-conjugated

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human HORMA domain-containing protein 1 protein (201-394AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HORMAD1

Target: HORMAD1 (HORMA Domain Containing 1 (HORMAD1))

Alternative Name: HORMAD1 (HORMAD1 Products)

Synonyms: CT46 antibody, NOHMA antibody, 4921522K05Rik antibody, Nohma antibody, RGD1564960 antibody, zgc:92129 antibody, HORMAD1 antibody, HORMA domain containing 1 antibody, HORMA domain containing 1 S homeolog antibody, HORMAD1 antibody, Hormad1 antibody, hormad1 antibody, hormad1.S antibody

Background:

Background: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.

Aliases: HORMAD1 antibody, NOHMA antibody, HORMA domain-containing protein 1 antibody, Cancer/testis antigen 46 antibody, CT46 antibody, Newborn ovary HORMA protein antibody

UniProt: Q86X24

Pathways: M Phase