HOMER1 antibody (AA 1-354)

Catalog No. ABIN7155877

Product Details anti-HOMER1 Antibody

Target: HOMER1 (Homer Homolog 1 (HOMER1))

Binding Specificity: AA 1-354

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOMER1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Homer protein homolog 1 protein (1-354AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HOMER1

Target: HOMER1 (Homer Homolog 1 (HOMER1))

Alternative Name: HOMER1 (HOMER1 Products)

Synonyms: HOMER antibody, HOMER1A antibody, HOMER1B antibody, HOMER1C antibody, SYN47 antibody, Ves-1 antibody, HOMER1 antibody, PSD-Zip45 antibody, homer1 antibody, zgc:100854 antibody, zgc:92844 antibody, HOMER1F antibody, Vesl-1 antibody, homer antibody, xhomer1 antibody, BEST:LD03829 antibody, CG11324 antibody, Dhom antibody, Dhomer antibody, Dm Homer antibody, Dmel\CG11324 antibody, Dvh antibody, Hom antibody, Homer antibody, LD03829 antibody, dhom antibody, homer scaffolding protein 1 antibody, homer scaffolding protein 1b antibody, homer scaffolding protein 1 L homeolog antibody, CG11324 gene product from transcript CG11324-RD antibody, HOMER1 antibody, Homer1 antibody, homer1b antibody, homer1.L antibody, homer antibody

Background:

Background: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity).

Aliases: HOME1_HUMAN antibody, Homer antibody, HOMER 1A antibody, HOMER 1B antibody, HOMER 1C antibody, Homer homolog 1 (Drosophila) antibody, homer homolog 1 antibody, Homer protein homolog 1 antibody, homer scaffolding protein 1 antibody, Homer, Drosophila, homolog of, 1 antibody, Homer, neuronal immediate early gene, 1 antibody, Homer-1 antibody, Homer1 antibody, HOMER1A antibody, HOMER1B antibody, HOMER1C antibody, SYN47 antibody, Ves 1 antibody

UniProt: Q86YM7

Pathways: Skeletal Muscle Fiber Development