HIPK3 antibody (AA 841-1130)

Catalog No. ABIN7155869

Product Details anti-HIPK3 Antibody

Target: HIPK3 (Homeodomain Interacting Protein Kinase 3 (HIPK3))

Binding Specificity: AA 841-1130

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIPK3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Homeodomain-interacting protein kinase 3 protein (841-1130AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HIPK3

Target: HIPK3 (Homeodomain Interacting Protein Kinase 3 (HIPK3))

Alternative Name: HIPK3 (HIPK3 Products)

Synonyms: HIPK3 antibody, pky antibody, yak1 antibody, dyrk6 antibody, fist3 antibody, MGC145460 antibody, DYRK6 antibody, FIST3 antibody, PKY antibody, YAK1 antibody, ANPK antibody, homeodomain interacting protein kinase 3 antibody, homeodomain interacting protein kinase 3 L homeolog antibody, HIPK3 antibody, hipk3.L antibody, hipk3 antibody, Hipk3 antibody

Background:

Background: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Aliases: Androgen receptor interacting nuclear protein kinase antibody, Androgen receptor-interacting nuclear protein kinase antibody, ANPK antibody, DYRK6 antibody, Fas interacting serine/threonine protein kinase antibody, Fas-interacting serine/threonine-protein kinase antibody, FIST antibody, FIST3 antibody, Hipk3 antibody, HIPK3_HUMAN antibody, homeodomain interacting protein kinase 3 antibody, Homeodomain-interacting protein kinase 3 antibody, Homolog of protein kinase YAK1 antibody, PKY antibody, RP24 297H17.5 antibody, YAK1 antibody

UniProt: Q9H422