HIPK2 antibody (AA 816-977)

Catalog No. ABIN7155865

Product Details anti-HIPK2 Antibody

Target: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Binding Specificity: AA 816-977

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIPK2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Homeodomain-interacting protein kinase 2 protein (816-977AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HIPK2

Target: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Alternative Name: HIPK2 (HIPK2 Products)

Synonyms: HIPK2 antibody, cb1009 antibody, si:dkey-16j24.2 antibody, si:dkey-239k7.1 antibody, wu:fk56d12 antibody, pro0593 antibody, MGC146781 antibody, PRO0593 antibody, 1110014O20Rik antibody, B230339E18Rik antibody, Stank antibody, PKM antibody, homeodomain interacting protein kinase 2 antibody, serine/threonine kinase antibody, homeodomain interacting protein kinase 2 L homeolog antibody, HIPK2 antibody, Smp_000720 antibody, hipk2 antibody, hipk2.L antibody, Hipk2 antibody

Background:

Background: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.

Aliases: hHIPk 2 antibody, hHIPk2 antibody, HIPK 2 antibody, Hipk2 antibody, HIPK2_HUMAN antibody, Homeodomain interacting protein kinase 2 antibody, Homeodomain-interacting protein kinase 2 antibody, Nbak1 antibody, Nuclear body-associated kinase 1 antibody, PRO0593 antibody, Sialophorin tail-associated nuclear serine/threonine-protein kinase antibody, Stank antibody

UniProt: Q9H2X6

Pathways: Cell Division Cycle