MEIS2 antibody (AA 377-470)

Catalog No. ABIN7155786

Product Details anti-MEIS2 Antibody

Target: MEIS2 (Meis Homeobox 2 (MEIS2))

Binding Specificity: AA 377-470

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEIS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Homeobox protein Meis2 protein (377-470AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MEIS2

Target: MEIS2 (Meis Homeobox 2 (MEIS2))

Alternative Name: MEIS2 (MEIS2 Products)

Synonyms: HsT18361 antibody, MRG1 antibody, A430109D20Rik antibody, Mrg1 antibody, Stra10 antibody, Meis2a.1 antibody, Meis2a.2 antibody, mrg1 antibody, MEIS2 antibody, hst18361 antibody, DKFZp469A1832 antibody, fa26d08 antibody, meis2.2 antibody, wu:fa26d08 antibody, meis2 antibody, meis2.1 antibody, Meis homeobox 2 antibody, Meis homeobox 2 L homeolog antibody, Meis homeobox 2a antibody, Meis homeobox 2b antibody, MEIS2 antibody, Meis2 antibody, meis2.L antibody, meis2 antibody, meis2a antibody, meis2b antibody

Background:

Background: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element, MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5\\\'-CGGTCA-3\\\', in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5\\\'-TGACAG-3\\\'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription, isoform 5 cannot activate DRD1 transcription.

Aliases: Homeobox protein Meis2 antibody, HsT18361 antibody, Meis (mouse) homolog 2 antibody, Meis homeobox 2 antibody, Meis homolog 2 antibody, Meis1 myeloid ecotropic viral integration site 1 homolog 2 (mouse) antibody, Meis1 myeloid ecotropic viral integration site 1 homolog 2 antibody, Meis1 related gene 1 antibody, Meis1 related protein 1 antibody, Meis1-related protein 1 antibody, MEIS2 antibody, MEIS2_HUMAN antibody, MGC2820 antibody, MRG1 antibody, TALE homeobox protein Meis2 antibody

UniProt: O14770