SUV420H2/KMT5C antibody (AA 235-345) (Biotin)

Catalog No. ABIN7155488

Product Details anti-SUV420H2/KMT5C Antibody (Biotin)

Target: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Binding Specificity: AA 235-345

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV420H2/KMT5C antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Histone-lysine N-methyltransferase KMT5C protein (235-345aa)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SUV420H2/KMT5C

Target: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Alternative Name: KMT5C (SUV420H2 Products)

Synonyms: zgc:162876 antibody, KMT5C antibody, BC024816 antibody, Suv4-20h2 antibody, lysine methyltransferase 5C antibody, suppressor of variegation 4-20 homolog 2 (Drosophila) antibody, lysine (K)-specific methyltransferase 5C L homeolog antibody, KMT5C antibody, kmt5c antibody, SUV420H2 antibody, kmt5c.L antibody, Kmt5c antibody

Background:

Background: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).

Aliases: Histone-lysine N-methyltransferase KMT5C (EC 2.1.1.43) (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2), KMT5C, SUV420H2

UniProt: Q86Y97