Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

MLL5/KMT2E antibody (AA 182-316) (HRP)

MLL5 Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN7155469
  • Target See all MLL5/KMT2E (MLL5) Antibodies
    MLL5/KMT2E (MLL5) (Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog) (MLL5))
    Binding Specificity
    • 10
    • 8
    • 4
    • 3
    • 3
    • 1
    • 1
    AA 182-316
    Reactivity
    • 35
    • 14
    • 11
    Human
    Host
    • 34
    • 2
    Rabbit
    Clonality
    • 36
    Polyclonal
    Conjugate
    • 17
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MLL5/KMT2E antibody is conjugated to HRP
    Application
    • 24
    • 16
    • 4
    • 4
    • 3
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Histone-lysine N-methyltransferase 2E protein (182-316AA)
    Isotype
    IgG
    Top Product
    Discover our top product MLL5 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    MLL5/KMT2E (MLL5) (Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog) (MLL5))
    Alternative Name
    KMT2E (MLL5 Products)
    Synonyms
    HDCMC04P antibody, MLL5 antibody, 1810033J14Rik antibody, 9530077A04Rik antibody, D230038D11Rik antibody, Mll5 antibody, lysine methyltransferase 2E antibody, lysine (K)-specific methyltransferase 2E antibody, KMT2E antibody, Kmt2e antibody
    Background

    Background: Histone methyltransferase that specifically mono- and dimethylates \'Lys-4\' of histone H3 (H3K4me1 and H3K4me2). H3 \'Lys-4\' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.

    Aliases: HDCMC04P antibody, Histone lysine N methyltransferase MLL5 antibody, Histone-lysine N-methyltransferase MLL5 antibody, KMT2E antibody, Lysine N methyltransferase 2E antibody, Lysine N-methyltransferase 2E antibody, MGC70452 antibody, Mll5 antibody, MLL5_HUMAN antibody, Myeloid/lymphoid or mixed lineage leukemia 5 (trithorax homolog, Drosophila) antibody, Myeloid/lymphoid or mixed lineage leukemia 5 antibody, Myeloid/lymphoid or mixed lineage leukemia protein 5 antibody, Myeloid/lymphoid or mixed-lineage leukemia protein 5 antibody

    UniProt
    Q8IZD2
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Warburg Effect
You are here:
Support