H2AFB1 antibody (AA 1-115) (Biotin)

Catalog No. ABIN7155374

Product Details anti-H2AFB1 Antibody (Biotin)

Target: H2AFB1 (H2A Histone Family, Member B1 (H2AFB1))

Binding Specificity: AA 1-115

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This H2AFB1 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Histone H2A-Bbd type 1 protein (1-115AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for H2AFB1

Target: H2AFB1 (H2A Histone Family, Member B1 (H2AFB1))

Alternative Name: H2AFB1 (H2AFB1 Products)

Synonyms: H2A.Bbd antibody, H2A histone family member B1 antibody, H2AFB1 antibody

Background:

Background: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.

Aliases: H2AB1 antibody, H2AFB1 antibody, Histone H2A-Bbd type 1 antibody, H2A Barr body-deficient antibody, H2A.B antibody, H2A.Bbd antibody

UniProt: P0C5Y9

Pathways: Telomere Maintenance