MYSM1 antibody (AA 170-311)

Catalog No. ABIN7155352

Product Details anti-MYSM1 Antibody

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Binding Specificity: AA 170-311

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYSM1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Histone H2A deubiquitinase MYSM1 protein (170-311AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MYSM1

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Alternative Name: MYSM1 (MYSM1 Products)

Synonyms: 2A-DUB antibody, 2ADUB antibody, RP4-592A1.1 antibody, C130067A03Rik antibody, C530050H10Rik antibody, RGD1311787 antibody, 2adub antibody, Myb like, SWIRM and MPN domains 1 antibody, myb-like, SWIRM and MPN domains 1 antibody, Myb like, SWIRM and MPN domains 1 L homeolog antibody, MYSM1 antibody, Mysm1 antibody, mysm1.L antibody

Background:

Background: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.

Aliases: 2A-DUB antibody, 2ADUB antibody, Histone H2A deubiquitinase antibody, Histone H2A deubiquitinase MYSM1 antibody, KIAA1915 antibody, Myb like SWIRM and MPN domains 1 antibody, Myb like, SWIRM and MPN domain containing protein antibody, Myb like, SWIRM and MPN domains 1 antibody, Myb-like antibody, Myb-like, SWIRM and MPN domains 1 antibody, MYSM 1 antibody, mysm1 antibody, MYSM1 Myb-like, SWIRM and MPN domains 1 antibody, MYSM1_HUMAN antibody, RP4-592A1.1 antibody, SWIRM and MPN domain-containing protein 1 antibody

UniProt: Q5VVJ2

Pathways: Chromatin Binding