Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

HDAC1 antibody (AA 1-482)

HDAC1 Reactivity: Human ELISA, IHC, IF, ChIP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7155301
  • Target See all HDAC1 Antibodies
    HDAC1 (Histone Deacetylase 1 (HDAC1))
    Binding Specificity
    • 16
    • 13
    • 8
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-482
    Reactivity
    • 138
    • 75
    • 60
    • 9
    • 8
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Human
    Host
    • 118
    • 22
    • 2
    Rabbit
    Clonality
    • 117
    • 25
    Polyclonal
    Conjugate
    • 98
    • 8
    • 7
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This HDAC1 antibody is un-conjugated
    Application
    • 103
    • 73
    • 39
    • 38
    • 26
    • 18
    • 14
    • 12
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Histone deacetylase 1 protein (1-482AA)
    Isotype
    IgG
    Top Product
    Discover our top product HDAC1 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200, IF:1:100-1:500,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    HDAC1 (Histone Deacetylase 1 (HDAC1))
    Alternative Name
    HDAC1 (HDAC1 Products)
    Background

    Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates \\\'Lys-310\\\' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

    Aliases: DKFZp686H12203 antibody, GON 10 antibody, HD1 antibody, HDAC 1 antibody, HDAC1 antibody, HDAC1_HUMAN antibody, Histone deacetylase 1 antibody, Reduced potassium dependency yeast homolog like 1 antibody, RPD3 antibody, RPD3L1 antibody

    UniProt
    Q13547
    Pathways
    Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis
You are here:
Support