PDE8A antibody (AA 596-829)

Catalog No. ABIN7155164

Product Details anti-PDE8A Antibody

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Binding Specificity: AA 596-829

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8A antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3\',5\'-cyclic phosphodiesterase 8A protein (596-829AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PDE8A

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Alternative Name: PDE8A (PDE8A Products)

Background:

Background: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 \'Ser-259\' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).

Aliases: 5''-cyclic phosphodiesterase 8A antibody, cAMP specific cyclic nucleotide phosphodiesterase 8A antibody, FLJ16150 antibody, High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A antibody, High affinity cAMP-specific and IBMX-insensitive 3'' antibody, HsT19550 antibody, PDE 8A antibody, PDE8A antibody, PDE8A_HUMAN antibody, Phosphodiesterase 8A antibody, Phosphodiesterase8A antibody, Weakly similar to 3'5' cyclic nucleotide phosphodiesterase antibody

UniProt: O60658

Pathways: cAMP Metabolic Process