GNAS antibody (AA 1-394)

Catalog No. ABIN7154707

Product Details anti-GNAS Antibody

Target: GNAS (GNAS Complex Locus (GNAS))

Binding Specificity: AA 1-394

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNAS antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Guanine nucleotide-binding protein G(s) subunit alpha isoforms short protein (1-394AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GNAS

Target: GNAS (GNAS Complex Locus (GNAS))

Alternative Name: GNAS (GNAS Products)

Background:

Background: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).

Aliases: Adenylate cyclase-stimulating G alpha protein antibody, AHO antibody, alternative gene product encoded by XL-exon antibody, C20orf45 antibody, extra large alphas protein antibody, GNAS antibody, GNAS complex locus antibody, GNAS1 antibody, GNAS1 gene, formerly antibody, GNAS1, formerly antibody, GNAS2_HUMAN antibody, GPSA antibody, GSA antibody, GSP antibody, guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1 antibody, guanine nucleotide regulatory protein antibody, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short antibody, guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas antibody, NESP antibody, neuroendocrine secretory protein antibody, PHP1A antibody, PHP1B antibody, PHP1C antibody, POH antibody, protein ALEX antibody, secretogranin VI antibody

UniProt: P63092

Pathways: Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis