VAV3 antibody (AA 562-674)

Catalog No. ABIN7154660

Product Details anti-VAV3 Antibody

Target: VAV3 (Vav 3 Oncogene (VAV3))

Binding Specificity: AA 562-674

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VAV3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Guanine nucleotide exchange factor VAV3 protein (562-674AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for VAV3

Target: VAV3 (Vav 3 Oncogene (VAV3))

Alternative Name: VAV3 (VAV3 Products)

Synonyms: RGD1565941 antibody, A530094I06Rik antibody, AA986410 antibody, Idd18.1 antibody, vav guanine nucleotide exchange factor 3 antibody, vav 3 guanine nucleotide exchange factor antibody, vav 3 oncogene antibody, VAV3 antibody, Vav3 antibody

Background:

Background: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).

Aliases: FLJ40431 antibody, Guanine nucleotide exchange factor VAV3 antibody, Protein vav 3 antibody, Protein vav3 antibody, RGD1565941 antibody, VAV 3 antibody, Vav 3 guanine nucleotide exchange factor antibody, VAV 3 oncogene antibody, VAV 3 protein antibody, VAV-3 antibody, Vav3 antibody, VAV3 oncogene antibody, VAV3 protein antibody, VAV3_HUMAN antibody

UniProt: Q9UKW4

Pathways: Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway