GANP antibody (AA 292-435)

Catalog No. ABIN7153843

Product Details anti-GANP Antibody

Target: GANP (MCM3AP) (Minichromosome Maintenance Complex Component 3 Associated Protein (MCM3AP))

Binding Specificity: AA 292-435

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GANP antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Germinal-center associated nuclear protein (292-435AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GANP

Target: GANP (MCM3AP) (Minichromosome Maintenance Complex Component 3 Associated Protein (MCM3AP))

Alternative Name: MCM3AP (MCM3AP Products)

Synonyms: GANP antibody, MAP80 antibody, SAC3 antibody, mKIAA0572 antibody, minichromosome maintenance complex component 3 associated protein antibody, germinal-center associated nuclear protein antibody, Mcm3ap antibody, MCM3AP antibody, mcm3ap antibody, LOC100026233 antibody

Background:

Background: Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.

Aliases: 80 kDa MCM3 associated protein antibody, 80 kDa MCM3-associated protein antibody, FLJ44336 antibody, FLJ45306 antibody, Germinal center associated nuclear protein antibody, KIAA0572 antibody, MAP80 antibody, MCM3 import protein antibody, MCM3 minichromosome maintenance deficient 3 associated protein antibody, MCM3A antibody, MCM3A_HUMAN antibody, Mcm3ap antibody, Minichromosome maintenance complex component 3 associated protein antibody, Minichromosome maintenance deficient 3 associated protein antibody, Minichromosome maintenance protein 3 associated protein antibody, Protein GANP antibody, SAC3 antibody

UniProt: O60318

Pathways: Protein targeting to Nucleus