WDR59 antibody (AA 619-862) (Biotin)

Catalog No. ABIN7153710

Product Details anti-WDR59 Antibody (Biotin)

Target: WDR59 (WD Repeat Domain 59 (WDR59))

Binding Specificity: AA 619-862

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR59 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human GATOR complex protein WDR59 protein (619-862AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for WDR59

Target: WDR59 (WD Repeat Domain 59 (WDR59))

Alternative Name: WDR59 (WDR59 Products)

Synonyms: 5430401O09Rik antibody, Cdw12 antibody, WD repeat domain 59 antibody, WDR59 antibody, Wdr59 antibody

Background:

Background: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).

Aliases: WDR59 antibody, KIAA1923 antibody, FP977 antibody, GATOR complex protein WDR59 antibody, WD repeat-containing protein 59 antibody

UniProt: Q6PJI9