Gasdermin A antibody (AA 64-172)

Catalog No. ABIN7153647

Product Details anti-Gasdermin A Antibody

Target: Gasdermin A (GSDMA)

Binding Specificity: AA 64-172

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gasdermin A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Gasdermin-A protein (64-172AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Gasdermin A

Target: Gasdermin A (GSDMA)

Alternative Name: GSDMA (GSDMA Products)

Synonyms: BB149167 antibody, Gsdm antibody, Gsdm1 antibody, Gsdma1 antibody, H312E antibody, GSDM1 antibody, GSDM antibody, gasdermin A antibody, Gsdma antibody, GSDMA antibody

Background:

Background: May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).

Aliases: GSDMA antibody, GSDM antibody, GSDM1 antibody, FKSG9Gasdermin-A antibody, Gasdermin-1 antibody

UniProt: Q96QA5