FZD4 antibody (AA 37-222)
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- Target See all FZD4 Antibodies
- FZD4 (Frizzled Family Receptor 4 (FZD4))
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Binding Specificity
- AA 37-222
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FZD4 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Frizzled-4 protein (37-222AA)
- Isotype
- IgG
- Top Product
- Discover our top product FZD4 Primary Antibody
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- Application Notes
- Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- FZD4 (Frizzled Family Receptor 4 (FZD4))
- Alternative Name
- FZD4 (FZD4 Products)
- Synonyms
- CG4626 antibody, DFz4 antibody, Dfz4 antibody, Dm Fz4 antibody, Dmel\\CG4626 antibody, Fz4 antibody, anon-WO0170980.10 antibody, anon-WO0170980.11 antibody, fz1 antibody, zg01 antibody, CD344 antibody, EVR1 antibody, FEVR antibody, FZD4S antibody, Fz-4 antibody, FzE4 antibody, GPCR antibody, hFz4 antibody, frizzled4 antibody, fz4 antibody, FZ-4 antibody, frizzled 4 antibody, frizzled class receptor 4 antibody, frizzled-4 antibody, frizzled class receptor 4 S homeolog antibody, fz4 antibody, fzd4 antibody, Tsp_10376 antibody, FZD4 antibody, Fzd4 antibody, fzd4.S antibody
- Background
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Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Aliases: CD 344 antibody, CD 344 antigen antibody, CD344 antibody, CD344 antigen antibody, EVR1 antibody, FEVR antibody, Frizzled (Drosophila) homolog 4 antibody, Frizzled 4 antibody, Frizzled family receptor 4 antibody, Frizzled homolog 4 (Drosophila) antibody, Frizzled-4 antibody, Fz 4 antibody, Fz-4 antibody, Fz4 antibody, FZD4 antibody, FZD4_HUMAN antibody, FZD4S antibody, FzE4 antibody, GPCR antibody, hFz4 antibody, MGC34390 antibody, WNT receptor frizzled 4 antibody
- UniProt
- Q9ULV1
- Pathways
- WNT Signaling, Hormone Transport, Sensory Perception of Sound
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