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FZD4 antibody (AA 37-222)

FZD4 Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7153185
  • Target See all FZD4 Antibodies
    FZD4 (Frizzled Family Receptor 4 (FZD4))
    Binding Specificity
    • 15
    • 10
    • 8
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 37-222
    Reactivity
    • 64
    • 52
    • 18
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Host
    • 69
    • 6
    • 5
    • 4
    Rabbit
    Clonality
    • 75
    • 9
    Polyclonal
    Conjugate
    • 36
    • 7
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FZD4 antibody is un-conjugated
    Application
    • 61
    • 33
    • 20
    • 13
    • 13
    • 7
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Frizzled-4 protein (37-222AA)
    Isotype
    IgG
    Top Product
    Discover our top product FZD4 Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    FZD4 (Frizzled Family Receptor 4 (FZD4))
    Alternative Name
    FZD4 (FZD4 Products)
    Synonyms
    CG4626 antibody, DFz4 antibody, Dfz4 antibody, Dm Fz4 antibody, Dmel\\CG4626 antibody, Fz4 antibody, anon-WO0170980.10 antibody, anon-WO0170980.11 antibody, fz1 antibody, zg01 antibody, CD344 antibody, EVR1 antibody, FEVR antibody, FZD4S antibody, Fz-4 antibody, FzE4 antibody, GPCR antibody, hFz4 antibody, frizzled4 antibody, fz4 antibody, FZ-4 antibody, frizzled 4 antibody, frizzled class receptor 4 antibody, frizzled-4 antibody, frizzled class receptor 4 S homeolog antibody, fz4 antibody, fzd4 antibody, Tsp_10376 antibody, FZD4 antibody, Fzd4 antibody, fzd4.S antibody
    Background

    Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

    Aliases: CD 344 antibody, CD 344 antigen antibody, CD344 antibody, CD344 antigen antibody, EVR1 antibody, FEVR antibody, Frizzled (Drosophila) homolog 4 antibody, Frizzled 4 antibody, Frizzled family receptor 4 antibody, Frizzled homolog 4 (Drosophila) antibody, Frizzled-4 antibody, Fz 4 antibody, Fz-4 antibody, Fz4 antibody, FZD4 antibody, FZD4_HUMAN antibody, FZD4S antibody, FzE4 antibody, GPCR antibody, hFz4 antibody, MGC34390 antibody, WNT receptor frizzled 4 antibody

    UniProt
    Q9ULV1
    Pathways
    WNT Signaling, Hormone Transport, Sensory Perception of Sound
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