FZD1 antibody (AA 125-225)

Catalog No. ABIN7153179

Product Details anti-FZD1 Antibody

Target: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Binding Specificity: AA 125-225

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FZD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Frizzled-10 protein (125-225AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FZD1

Target: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Alternative Name: FZD1 (Fzd1 Products)

Background:

Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Aliases: CD 350 antibody, CD 350 antigen antibody, CD350 antibody, Frizzled (Drosophila) homolog 10 antibody, Frizzled-10 antibody, FZ 10 antibody, Fz-10 antibody, FZ10 antibody, FZD 10 antibody, FZD10 antibody, FZD10_HUMAN antibody, FzE 7 antibody, FzE7 antibody, hFz 10 antibody, hFz10 antibody

UniProt: Q9ULW2

Pathways: WNT Signaling, Asymmetric Protein Localization