FOXN4 antibody (AA 89-194) (Biotin)

Catalog No. ABIN7153077

Product Details anti-FOXN4 Antibody (Biotin)

Target: FOXN4 (Forkhead Box N4 (FOXN4))

Binding Specificity: AA 89-194

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXN4 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Forkhead box protein N4 protein (89-194AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FOXN4

Target: FOXN4 (Forkhead Box N4 (FOXN4))

Alternative Name: FOXN4 (FOXN4 Products)

Synonyms: whn antibody, whna antibody, forkhead box N4 antibody, forkhead box N4 S homeolog antibody, FOXN4 antibody, foxn4 antibody, Foxn4 antibody, foxn4.S antibody

Background:

Background: Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5\'-ACGC-3\'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).

Aliases: FOXN4Forkhead box protein N4 antibody

UniProt: Q96NZ1