FERMT2 antibody (AA 155-232)

Catalog No. ABIN7152702

Product Details anti-FERMT2 Antibody

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Binding Specificity: AA 155-232

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FERMT2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Fermitin family homolog 2 protein (155-232AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FERMT2

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Alternative Name: FERMT2 (FERMT2 Products)

Synonyms: AA960555 antibody, Kindlin-2 antibody, Mig2 antibody, Plekhc1 antibody, KIND2 antibody, MIG2 antibody, PLEKHC1 antibody, UNC112 antibody, UNC112B antibody, mig-2 antibody, fermitin family member 2 antibody, Fermt2 antibody, FERMT2 antibody

Background:

Background: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading, this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.

Aliases: FLJ34213 antibody, FLJ44462 antibody, UNC112 antibody, FERM2_HUMAN antibody, Fermitin family homolog 2 antibody, Fermt2 antibody, KIND2 antibody, Kindlin-2 antibody, MIG-2 antibody, MIG2 antibody, Mitogen-inducible gene 2 protein antibody, PH domain-containing family C member 1 antibody, Pleckstrin homology domain containing family C (with FERM domain) member 1 antibody, Pleckstrin homology domain-containing family C member 1 antibody, PLEKHC1 antibody, UNC112B antibody

UniProt: Q96AC1

Pathways: Cell-Cell Junction Organization